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Mancheng Tang

Tenure-track Associate Professor

  • Tel: +86-02134204096
  • Email: tangmc@sjtu.edu.cn
  • Address: 2-303

Selected Publications

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    Liu L., Tang M.-C.*, Tang Y.* “Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes that are Precursors to Epoxycyclohexenol Natural Products.” J. Am. Chem. Soc. 2019, 141, 19538-19541.

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    Tang M.-C.#, Fischer C. R.#, Chari J. V., Tan D., Suresh S., Chu A., Miranda M., Smith J., Zhang Z., Garg N., St Onge R. P.*, Tang Y.* “Thioesterase-catalyzed aminoacylation and thiolation of polyketides in fungi.” J. Am. Chem. Soc. 2019, 141, 8198-8206.

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    Tan D.#, Jamieson C. S.#, Ohashi M., Tang M.-C.*, Houk K. N.*, Tang Y.* “Genome-mined Diels-Alderase catalyzes the formation of the cis-octahydrodecalins of varicidin A and B.” J. Am. Chem. Soc. 2019,141, 769-773.

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    Tang M.-C.#, Zou Y.#, Yee D., Tang Y.* “Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT5891.”AIChE J. 2018, 64, 4182-4186.

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    Harvey C. J. B.#Tang M.#, Schlecht U., Horecka J., Fischer C. R., Lin H.-C., Li J., Naughton B., Cherry J., Miranda M., Li Y. F., Chu A. M., Hennessy J. R., Vandova G. A., Inglis D., Aiyar R., Steinmetz L. M., Davis R. W., Medema M. H., Sattely E., Khosla C., St Onge R. P., Tang Y., Hillenmeyer M. H.* “HEx: a heterologous expression platform for the discovery of fungal natural products.” Sci. Adv. 2018, 4: eaar5459.

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    Li L.#Tang M.-C.#, Tang S., Gao S., Soliman S., Hang L., Xu W., Ye T., Watanabe K., Tang Y.* “Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.” J. Am. Chem. Soc. 2018, 140, 2067-2071.

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    Tang M.-C.#, Cui X.#, He X., Ding Z., Zhu T., Tang Y.*, Li D.* “Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.” Org. Lett. 2017, 19, 5736-5739.

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    Hang L.#Tang M.-C.#, Harvey C. J. B., Page C. G., Li J., Hung Y.-S., Liu N., Hillenmeyer M. E., Tang Y.* “Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain.” Angew. Chem. Int. Ed. 2017, 56, 9556-9560.

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    Tang M.-C.#, Zou Y.#, Watanabe K., Walsh C. T.*, Tang Y.* “Oxidative Cyclization in Natural Product Biosynthesis.” Chem. Rev. 2017, 117, 5226-5333. (Invited review)

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    Tang M.-C., Lin H.-C., Li D., Zou Y., Li J., Xu W., Cacho R. A., Hillenmeyer M. E., Garg N. K., Tang Y.* “Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.” J. Am. Chem. Soc. 2015, 137, 13724-13727.