Characterization of novel microbial natural product biosynthetic gene clusters;
Engineering of natural product structure diversity by synthetic biology methods.
Elucidation of novel enzymes and mechanisms of catalysis
NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation, ACS Chemical Biology, 2018.09, 13(9): 2387~2391
Functional Characterization of PyrG, an Unusual Nonribosomal Peptide Synthetase Module from the Pyridomycin Biosynthetic Pathway, ChemBioChem, 2016.08.3, 17(15): 1421~1425
Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027, Journal of Antibiotics, 2016.10, 69(10): 731~740
Mechanisms of Self-Resistance in the Platensimycin- and Platencin-Producing Streptomyces platensis MA7327 and MA7339 Strains , Chemist ry & Biology, 2014.3.20, 21(3): 389~397