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Shuangjun Lin

Distinguished Professor

  • Tel: +86-021
  • Email: linsj@sjtu.edu.cn
  • Address: 1954 Huashan Rd/ 800 Dongchuan Rd
  • Lab Web: http://mml.sjtu.edu.cn/

Education and Research Experience

  • Education
  • 2002.08    Ph.D. degree in organic chemistry. Institute of Chemistry, Chinese Academy of Sciences
  • 1999.07    M.Sc. degree in organic chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
  • 1996.07    B. Sc. degree in chemistry, Ji Lin University
  • Research experiences
  • 2008.11-present    Professor School of Life Sciences and Biotechnology, Shanghai Jiao University
  • 2005.09-2008.09  Research Associate School of Pharmacy, University of Wisconsin-Madison, USA
  • 2002.12-2005.08  Postdoctoral Fellow Department of Chemistry, University of Alberta, Canada
  • 2002.09-2002.11  Assistant The Institute of Chemistry, CAS

Research Interests

Biosynthesis of natural products

Biosynthesis of natural products

Discovery and structural elucidation of biologically active natural products...

Discovery and structural elucidation of biologically active natural products from special microorganisms.

Enzymatic mechanism and application of enzymes in organic synthesis and synt...

Enzymatic mechanism and application of enzymes in organic synthesis and synthetic biology

Selected Publications

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    Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc 2017, 139(34):11887-94.

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    Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*. Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway. Science China-Chemistry, 2016, 59, 1224-8.

    ?  

    Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*. Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives. ACS Catal. 2016, 6, 2831-5.

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    Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*. An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal., 2016, 6, 788-92.

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    Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*. Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch. Angew Chem Int Ed, 2013, 52, 12951-5.

  • ?  

    Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond. J Am Chem Soc. 2013, 135, 1739-48.

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    Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett. 2012, 14, 2300-3.

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    Lin S, Van Lanen SG and Shen B*. A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4183-8

    ?  

    Lin S, Horsman GP, Chen Y, Li W, Shen B*. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2009, 131, 16410-7

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    Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z. Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem. 2011, 286, 20648-57

Teaching Experiences

  • Biochemistry;
  • Medicinal Chemistry of Natural Products
  • Grants from:
  • National Natural Science Foundation of China
  • National Science and Technology Information System

Selected Grants

Students