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Ping Yong

Research Associate Professor / Associate Researcher

  • Tel: +86-021
  • Email: yoping@sjtu.edu.cn
  • Address: Bio-X Institutes, 800 Dongchuan Rd, Life Science Buildings #1, Rm 204
  • Lab Web: /teacher/Lab/yoping
  • Principle Investigator (PI). The main focus of my lab is the molecular and genetic basis of sleep and neurodegeneration.

Education and Research Experience

  • 2000-2004   Fudan University  BS
  • 2004-2009   Fudan University  Ph.D.   
  • 2009-2010   Harvard University  Postdoc
  • 2010-2012   Colorado State University  Postdoc
  • 2013-present  Shanghai Jiao Tong University  Associate Professor, PI

Research Interests

Sleep and Sleep Disturbance

What is the biological basis for sleep, and how do neurons and molecules within the brain change during sleep:wake transition? How sleep impacts on memory at a cellular level? Which specific molecules or neurons contributes to sleep and memory impairments in Alzheimer’s disease (AD)? To answer these and other related questions, we study Drosophila melanogaster, as well as mice for further investigation. From a human health perspective, gaining a better understanding of underlying biological mechanisms of complex behaviors such as sleep and memory in Drosophila will provide intriguing insights which can be applied to the more complex mammalian brain. Research in our lab is therefore aim to elucidate the molecular and cellular processes that drive such plastic behaviors, and their roles in disease pathophysiology. The main focus of our research is the molecular and genetic basis of sleep and memory.

Sleep Disturbance and Neurodegeneration

What is the biological basis for sleep, and how do neurons and molecules within the brain change during sleep:wake transition? How sleep impacts on memory at a cellular level? Which specific molecules or neurons contributes to sleep and memory impairments in Alzheimer’s disease (AD)? To answer these and other related questions, we study Drosophila melanogaster, as well as mice for further investigation. From a human health perspective, gaining a better understanding of underlying biological mechanisms of complex behaviors such as sleep and memory in Drosophila will provide intriguing insights which can be applied to the more complex mammalian brain. Research in our lab is therefore aim to elucidate the molecular and cellular processes that drive such plastic behaviors, and their roles in disease pathophysiology. The main focus of our research is the molecular and genetic basis of sleep and memory.

Selected Publications

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    Ping Y*, Shao L, Li M, Yang L, Zhang J. Contribution of Social Influences Through Superposition of Visual and Olfactory Inputs to Circadian Re-entrainment. iScience. 2020 Feb 21;23(2):100856. 

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    Feng G, Song Q, Zhang J, L Shao, Li M, Yang L, Ping Y* (2018) Control of sleep onset by Shal/Kv4 channels in Drosophila circadian neurons. Journal of Neuroscience 38(42):9059-9071

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    Song Q, Feng G, Zhang J, Xia X, Ji M, Lv L, Ping Y* (2017) NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest:activity Rhythms in Drosophila. SLEEP 40(12):1-13

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    Feng G, Pang J, Yi X, Song Q, Zhang J, Li C, He G, Ping Y* (2018) Down-regulation of KV4 channel in Drosophila mushroom body neurons contributes to Aβ42-induced courtship memory deficits. Neuroscience. 370:236-245.

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    Song Q, Feng G, Huang Z, Chen X, Chen Z, Ping Y* (2017) Aberrant axonal arborization of PDF neurons induced by Aβ42-mediated JNK activation underlies sleep disturbance in an Alzheimer's Model. Molecular Neurobiology. 54(8):6317-6328.

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    Ping Y, Hahm ET, Waro G , Song Q, Vo-Ba DA, Licursi A, Bao H, Ganoe L, Finch K, Tsunoda S* (2015). Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer's Model. PLOS Genetics 11(3):e1005025.

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    Ping Y & Tsunoda S* (2012). Inactivity-Induced Increase in nAChRs Up-Regulates Shal K+ Channels to Stabilize Synaptic Potentials. Nature Neuroscience 15:90-97.

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    Ping Y, Waro G, Licursi A, Smith S, Vo-Ba DA, Tsunoda S* (2011) Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. PLoS One 6:e16043.

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    Ping Y, Huang H, Zhang XJ, Yang XL* (2008) Melatonin potentiates rod signals to ON type bipolar cells in fish retina. Journal of Physiology 586:2683-2694

Academic Rewards

  • Shanghai Rising-Star Program (2019)

Teaching Experiences

  • Genetics and Development;
  • 遗传发育与神经精神疾病
  • Supported by National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality and Shanghai Municipal Education Commission.

Selected Grants

Students